Increased 68Ga-FAPI Uptake in Benign Metastasizing Leiomyoma

Abstract

Abstract Benign metastasizing leiomyomas (BMLs) are benign disseminated extrauterine tumors in patients with prior history of uterine leiomyomas and may occur years after hysterectomy. In this case, we presented 18F-FDG and 68Ga-FAPI PET/CT findings in a 37-year-old woman with benign leiomyoma metastasizing to lung and pelvis. The metastatic lesions demonstrated faint 18F-FDG but elevated 68Ga-FAPI activity, indicating the low level of glucose metabolism but excessive accumulation of activated fibroblasts in the BMLs. This case demonstrated that 68Ga-FAPI PET/CT may be potentially useful in the evaluation of BMLs.