177Lu-DOTATATE Therapy in a Case of Castrate-Resistant Prostate Cancer With Neuroendocrine Differentiation

Author:

Shu Qiaoqiao,Li Xianjun1,Chen Xi,Chen Yue,Cai Liang

Affiliation:

1. Department of Nuclear Medicine, Weifang People's Hospital, Shandong Province, People's Republic of China.

Abstract

Abstract An 84-year-old man with prostate cancer with neuroendocrine differentiation underwent PET/CT for staging. 68Ga–prostate-specific membrane antigen PET/CT did not show significant abnormal tracer accumulation, whereas 18F-OC (18F-AlF-NOTA-octreotide) PET/CT showed elevated tracer uptake at multiple sites throughout the body. Therefore, the patient opted to receive 1 cycle of 177Lu-DOTATATE peptide receptor radionuclide therapy with a dose of 200 mCi. Encouragingly, radiographic tumor remission and improvement of clinical symptoms were observed after only 1 cycle of treatment.

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

Radiology, Nuclear Medicine and imaging,General Medicine

Reference8 articles.

1. Proposed morphologic classification of prostate cancer with neuroendocrine differentiation;Am J Surg Pathol,2014

2. Clinical implications of neuroendocrine differentiation in prostate cancer;Prostate Cancer Prostatic Dis,2007

3. Prostate cancer with neuroendocrine differentiation—case report;J Med Life,2012

4. Neuroendocrine differentiation in prostate cancer: a mechanism of radioresistance and treatment failure;Front Oncol,2015

5. Excellent response to 177Lu-DOTATATE peptide receptor radionuclide therapy in a patient with progressive metastatic castration-resistant prostate Cancer with neuroendocrine differentiation after 177Lu-PSMA therapy;Clin Nucl Med,2019

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