False-Negative 68Ga-FAPI PET/CT in Pediatric Thyroid Medullary Carcinoma Seen With 68Ga-DOTATOC PET/CT and 18F-FDG PET/CT-Reference-Cited by-同舟云学术

False-Negative 68Ga-FAPI PET/CT in Pediatric Thyroid Medullary Carcinoma Seen With 68Ga-DOTATOC PET/CT and 18F-FDG PET/CT

Published:2024-05-08 Issue:7 Volume:49 Page:690-692
ISSN:1536-0229
Container-title:Clinical Nuclear Medicine
language:en
Short-container-title:Clin Nucl Med

Author:

Haidar Mohamad B.¹^ORCID,Abou Zeid Farah A.¹,Meguerian Zarouhie Z.²,Al-Ibraheem Akram N.³^ORCID,Noun Peter E.⁴

Affiliation:

1. Department of Diagnostic Radiology, American University of Beirut, Beirut, Lebanon

2. Department of Pathology, Saint George, Hospital University Medical Center, Beirut, Lebanon

3. Department of Nuclear Medicine and PET/CT, King Hussein Cancer Center, Amman, Jordan

4. Department of Pediatrics, Hematology Oncology, Saint George, Hospital University Medical Center, Beirut, Lebanon.

Abstract

Abstract In adults, 68Ga-FAP inhibitor (68Ga-FAPI) PET/CT outperforms 68Ga-radiolabeled somatostatin analog peptides (68Ga PET/CT) and 18F-FDG PET/CT in detecting thyroid lesions. This is the case of a 13-year-old boy newly diagnosed with medullary thyroid cancer with high calcitonin level. 68Ga PET/CT revealed the presence of only a primary thyroid lesion. Proven to be superior in detecting metastasis, 68Ga-FAPI PET/CT was performed. The results came out negative for primary and potential metastatic lesions. This case sheds shed light on false-negatives reported in 68Ga-FAPI PET/CT scans in pediatric patients, emphasizing the need for alternate radiotracers when a negative study is met.

Publisher

Ovid Technologies (Wolters Kluwer Health)

Reference8 articles.

1. Current guidelines for management of medullary thyroid carcinoma;Endocrinol Metab (Seoul),2021

2. Clinical impact of (68)Ga-DOTATATE PET-CT imaging in patients with medullary thyroid cancer;Ann Nucl Med,2020

3. Liver metastases from medullary thyroid carcinoma detected on 68Ga-FAPI-04 PET/CT;Endocrine,2021

4. [(68)Ga]Ga-DOTA-FAPI-04 PET/CT depicts metastases from medullary thyroid cancer that [(68)Ga]Ga-DOTATOC PET/CT missed;Eur J Nucl Med Mol Imaging,2023

5. Head-to-head comparison of [(68)Ga]Ga-DOTA.SA.FAPi and [(68)Ga]Ga-DOTANOC positron emission tomography/computed tomography imaging for the follow-up surveillance of patients with medullary thyroid cancer;Thyroid,2023