Age-Related Changes in Corneal Sensitivity

Author:

Nosch Daniela S.,Käser Emanuele,Bracher Tobias,Joos Roland E.

Abstract

Purpose: The aim of this prospective cross-sectional cohort study was to clinically test whether corneal sensation decreases with age, based on subject feedback (psychophysical method), and whether it correlates with general pain perception. Methods: Subjects were recruited from 2 equally large age groups: group A (18–30 years) and group B (50–70 years; n = 45 per group). The inclusion criteria were healthy eyes, Ocular Surface Disease Index ≤13, and no contact lens wear. Corneal sensitivity threshold (CST) measurements were performed twice during each of the 2 visits, with the aid of the new Swiss liquid jet esthesiometer for corneal sensitivity (SLACS) and Cochet–Bonnet (CB) esthesiometer. A general pain sensitivity score was obtained from all participants. Results: Ninety subjects completed the study (n = 45 per age group, average age in group A: 24.2 ± 2.94 years, group B: 58.5 ± 5.71 years). Statistically higher CSTs for age group B were only observed for SLACS (mean difference: 1.58 dB, P < 0.001). No correlation was observed between the pain score and the CSTs obtained with either esthesiometry method (r = 0.11, P = 0.25 for liquid jet and r=−0.076, P = 0.61 CB). Conclusions: A statistically significant decrease in corneal sensitivity was observed for the older age group with SLACS in this study, with CB however only a trend in the same direction was noted. General pain perception was not found to correlate with ocular surface sensation.

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

Ophthalmology

Reference71 articles.

1. Corneal nerves: structure, contents and function;Müller;Exp Eye Res.,2003

2. Density and organization of free nerve endings in the corneal epithelium of the rabbit;Rózsa;Pain,1982

3. Sensory experiences in humans and single-unit activity in cats evoked by polymodal stimulation of the cornea;Acosta;J Physiol.,2001

4. Sensations evoked by selective mechanical, chemical, and thermal stimulation of the conjunctiva and cornea;Acosta;Invest Ophthalmol Vis Sci.,2001

5. Neural basis of sensation in intact and injured corneas;Belmonte;Exp Eye Res.,2004

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