Novel Mechanisms Guide Innovative Molecular-Based Therapeutic Strategies for Fuchs Endothelial Corneal Dystrophy-Reference-Cited by-同舟云学术

Novel Mechanisms Guide Innovative Molecular-Based Therapeutic Strategies for Fuchs Endothelial Corneal Dystrophy

Published:2023-06-13 Issue:8 Volume:42 Page:929-933
ISSN:0277-3740
Container-title:Cornea
language:en
Short-container-title:

Author:

Chan Matilda F.¹²^ORCID,Pan Peipei³,Wolfreys Finn D.¹

Affiliation:

1. Department of Ophthalmology, University of California, San Francisco, CA;

2. Francis I. Proctor Foundation, University of California, San Francisco, CA; and

3. Center for Cerebrovascular Research, Department of Anesthesia and Perioperative Care, University of California, San Francisco, CA.

Abstract

Abstract: Major advances in genomics have dramatically increased our understanding of Fuchs endothelial corneal dystrophy (FECD) and identified diverse genetic causes and associations. Biomarkers derived from these studies have the potential to inform both clinical treatment and yield novel therapeutics for this corneal dystrophy.

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

Ophthalmology

Reference23 articles.

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2. Genome-wide association study identifies three novel loci in Fuchs endothelial corneal dystrophy;Afshari;Nat Commun.,2017

3. Fuchs endothelial corneal dystrophy: the vicious cycle of Fuchs pathogenesis;Ong Tone;Prog Retin Eye Res.,2021

4. The basics of epithelial-mesenchymal transition;Kalluri;J Clin Invest.,2009

5. Involvement of ZEB1 and Snail1 in excessive production of extracellular matrix in Fuchs endothelial corneal dystrophy;Okumura;Lab Invest.,2015

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1. Exploring single-cell RNA sequencing as a decision-making tool in the clinical management of Fuchs’ endothelial corneal dystrophy;Progress in Retinal and Eye Research;2024-09