Spontaneous Recovery of Pathological Fracture Caused by Medication-Related Osteonecrosis of the Jaw

Author:

Jung Joon Hyeok1,Kim Je Seong1,Kim Bong Chul1,Lee Jun12,Lim Hun Jun13

Affiliation:

1. Department of Oral and Maxillofacial Surgery, Daejeon Dental Hospital, Wonkwang University, Daejeon

2. Wonkwang Bone Regeneration Research Institute, Daejoen Dental Hospital, College of Dentistry, Wonkwang University, Daejeon, Republic of Korea

3. Wonkwang Dental Research Institute, Wonkwang Universtiy, Iksan, Republic of Korea

Abstract

Pathological fracture is one of the most serious complications in medication-related osteonecrosis of the jaw (MRONJ). This case is a report of an 87-year-old woman who had been diagnosed with pathological fracture due to MRONJ. The authors performed minimally invasive and conservative treatment, such as intraoral dressing, antibiotic therapy, and simple debridement, for patients with pathologic fractures due to MRONJ. After 1 year, the inflammatory symptoms disappeared and pathological fractures spontaneously recovered.

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

General Medicine,Otorhinolaryngology,Surgery

Reference13 articles.

1. Inhibition of oral mucosal cell wound healing by bisphosphonates;Landesberg;J Oral Maxillofac Surg,2008

2. Medication-related osteonecrosis of the jaw: 2014 update of BRONJ;You;J Korean Acad Advanc General Dent,2014

3. “Bis-phossy” jaws high and low-risk factors for bisphosphonate-induced osteonecrosis of the jaw;Abu-Id;J Craniomaxillofac Surg,2008

4. Pathologic fractures in bisphosphonate-related osteonecrosis of the jaw-review of the literature and review of our own cases;Otto;Craniomaxillofac Trauma Reconstr,2013

5. Treatment of pathologic fractures of the mandible in stage III medication-related osteonecrosis of the jaw-an observational study;Pichardo;J Craniomaxillofac Surg,2018

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