Assessing the clinical impact of CYP2C9 pharmacogenetic variation on phenytoin prescribing practice and patient response in an integrated health system

Author:

Fohner Alison E.,Ranatunga Dilrini K.,Thai Khanh K.,Lawson Brian L.,Risch Neil,Oni-Orisan Akinyemi,Jelalian Aline T.,Rettie Allan E.,Liu Vincent X.,Schaefer Catherine A.

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

Genetics (clinical),Genetics,Molecular Biology,Molecular Medicine,General Pharmacology, Toxicology and Pharmaceutics

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2. CYP2C9 polymorphism in patients with epilepsy: genotypic frequency analyzes and phenytoin adverse reactions correlation.;Twardowschy;Arq Neuropsiquiatr,2011

3. Genetic polymorphism of the CYP2C subfamily and excessive serum phenytoin concentration with central nervous system intoxication.;Ninomiya;Ther Drug Monit,2000

4. HLA-B*1502 increases the risk of phenytoin or lamotrigine induced stevens-johnson syndrome/toxic epidermal necrolysis: evidence from a meta-analysis of nine case-control studies.;Li;Drug Res (Stuttg,2015

5. Immune self-reactivity triggered by drug-modified HLA-peptide repertoire.;Illing;Nature,2012

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