Brachial-femoral pulse wave velocity in 2–4-year-old children: a feasibility study

Author:

Jones Melissa A.1,Whitaker Kara M.23,Paley Joshua L.4,Thrower Alexis5,Stoner Lee67,Barone Gibbs Bethany48

Affiliation:

1. Department of Human Movement Science, Oakland University, Rochester, Michigan, Departments of

2. Health and Human Physiology

3. Epidemiology, The University of Iowa, Iowa City, Iowa

4. Department of Health and Human Development, University of Pittsburgh, Pittsburgh, Pennsylvania

5. Department of Human Performance-Exercise Physiology, West Virginia University, Morgantown, West Virginia

6. Department of Exercise and Sports Science, University of North Carolina-Chapel Hill

7. Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina-Chapel Hill, Chapel Hill, North Carolina

8. Department of Epidemiology and Biostatistics, West Virginia University School of Public Health, Morgantown, West Virginia, USA

Abstract

Background Cardiovascular disease (CVD) progression occurs across the lifespan. However, available measures of CVD risk in young children are limited. Carotid-femoral pulse wave velocity (cfPWV) is a gold-standard, noninvasive measure of CVD risk that has been studied in children ages 6–18 years. Yet, cfPWV has been measured to a lesser extent in younger children, a population whose temperament or attention span may pose unique challenges. Brachial-femoral PWV (bfPWV) may be feasible, more acceptable, and could provide similar CVD risk assessment to cfPWV in younger children. This study aimed to determine the feasibility of bfPWV measurement in children ages 2–4 years including assessment of comparability of bfPWV to cfPWV normative data. Methods In 10 children (mean 2.9 ± 0.5 years), oscillometric cuffs were placed on the upper thigh and upper arm. Following a 5-min rest, cuffs were inflated to a subdiastolic pressure three times, and waveforms were captured. Procedures were repeated after a 15-min rest. Measured values were compared to age-predicted cfPWV extrapolated from published normative data in children 6–18 years of age. Results We successfully obtained at least one acceptable quality bfPWV scan in all participants. Among the subset with a repeated measurement (n = 5), mean (SD) difference between measurements was 0.013 (0.28) m/s. Mean bfPWV was slightly higher than age-predicted cfPWV (observed: 4.55 m/s; predicted: 3.99 m/s; P = 0.012) with larger residuals among younger children and those not reclined in a chair during measurement. Conclusion bfPWV appears to be feasible tool for noninvasive CVD risk assessment in children ages 2–4 years.

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

Advanced and Specialized Nursing,Assessment and Diagnosis,Cardiology and Cardiovascular Medicine,General Medicine,Internal Medicine

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3