Drugs in Focus: Domperidone-Reference-Cited by-同舟云学术

Drugs in Focus: Domperidone

Published:2023-05-09 Issue:2 Volume:77 Page:e13-e22
ISSN:0277-2116
Container-title:Journal of Pediatric Gastroenterology & Nutrition
language:en
Short-container-title:

Author:

Puoti Maria Giovanna¹,Assa Amit²,Benninga Marc³,Broekaert Ilse Julia⁴,Carpi Francisco Javier Martin⁵,Deganello Saccomani Marco⁶,Dolinsek Jernej⁷,Homan Matjaz⁸,Mas Emmanuel⁹,Miele Erasmo¹⁰,Tzivinikos Christos¹¹,Thomson Mike¹²,Borrelli Osvaldo¹

Affiliation:

1. Department of Paediatric Gastroenterology, Great Ormond Street Hospital for Children, London, UK

2. The Juliet Keidan Institute of Paediatric Gastroenterology and Nutrition, Shaare Zedek Medical Center, The Hebrew University, Jerusalem, Israel

3. Department of Paediatric Gastroenterology and Nutrition, Emma Children’s Hospital, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, The Netherlands

4. Department of Paediatrics, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany

5. Department of Paediatric Gastroenterology, Hepatology and Nutrition, Hospital Sant Joan de Déu, Barcelona, Spain

6. Department of Paediatrics, Woman’s & Child’s University Hospital of Verona, Verona, Italy

7. Department of Gastroenterology, Hepatology and Nutrition, University Medical Centre Maribor, Maribor, Slovenia

8. Department of Gastroenterology, Hepatology and Nutrition, Faculty of Medicine, University Medical Centre Ljubljana, Ljubljana, Slovenia

9. Service de Gastroentérologie, Hépatologie, Nutrition, Diabétologie et Maladies Héréditaires du Métabolisme, Hôpital des Enfants, CHU de Toulouse, F-31300 Toulouse, France, and IRSD, Université de Toulouse, INSERM, INRAE, ENVT, UPS, Toulouse, France

10. Department of Translational Medicine Science, Section of Paediatrics, University of Naples “Federico II”, Naples, Italy

11. Paediatric Gastroenterology Department, Al Jalila Children’s Specialty Hospital, Mohammed Bin Rashid University of Medicine and Health Sciences, Dubai, United Arab Emirates

12. Centre for Paediatric Gastroenterology, Sheffield Children’s Hospital, Weston Bank, Sheffield, UK.

Abstract

Domperidone is a peripheral dopamine-2 receptor antagonist with prokinetic and antiemetic properties. Its prokinetic effects are mainly manifest in the upper gastrointestinal (GI) tract. Currently its use is restricted to relief of nausea and vomiting in children older than 12 years for a short period of time. However, among (pediatric) gastroenterologists, domperidone is also used outside its authorized indication (“off label”) for treatment of symptoms associated with gastro-esophageal reflux disease, dyspepsia, and gastroparesis. Little is known about its efficacy in the treatment of GI motility disorders in children and controversial data have emerged in the pediatric literature. As its use is off label, appropriate knowledge of its efficacy is helpful to support an “off label/on evidence” prescription. Based on this, the purpose of this review is to summarize all evidence on the efficacy of domperidone for the treatment of GI disorders in infants and children and to report an overview of its pharmacological properties and safety profile.

Publisher

Wiley

Subject

Gastroenterology,Pediatrics, Perinatology and Child Health

Reference94 articles.

1. Domperidone: a peripherally acting dopamine 2-receptor antagonist.;Barone;Ann Pharmacother,1999

2. Summary of the 34th meeting of the Food and Drug Administration Gastrointestinal Drugs Advisory Committee. March 15 and 16, 1989 (omeprazole and domperidone).;Stern;Am J Gastroenterol,1989

3. Domperidone, a specific in vitro dopamine antagonist, devoid of in vivo central dopaminergic activity.;Laduron;Biochem Pharmacol,1979

4. Pharmacokinetics and dose proportionality of domperidone in healthy volunteers.;Huang;J Clin Pharmacol,1986

5. Review of the current status of prokinetic agents in gastroenterology.;McCallum;Am J Gastroenterol,1985

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