Do Polymorphisms Predict Hypnotherapy Response in Children With Functional Abdominal Pain Disorders: An Explorative Study

Author:

de Bruijn Clara M.A.1,Hovy Stefan W.2,Tromp Ellen3,Benninga Marc A.1,Hall Kathryn T.4,Vlieger Arine M.2

Affiliation:

1. Emma Children’s Hospital, Amsterdam UMC, University of Amsterdam, Pediatric Gastroenterology, Hepatology and Nutrition, Amsterdam, The Netherlands

2. Department of Pediatrics, St. Antonius Hospital, Nieuwegein, The Netherlands

3. Department of Statistics, St. Antonius Hospital, Nieuwegein, The Netherlands

4. Division of Preventive Medicine, Brigham and Womens Hospital and Harvard Medical School, Boston, and Boston Public Health Commission, Boston, MA.

Abstract

Genetic variations, in specific COMT, OPRM1, and MAO-A polymorphisms, have been associated with hypnotizability in adults. The aim of this exploratory study was to investigate whether these polymorphisms are also associated with response to hypnotherapy (HT) in children. Patients (8–18 years, n = 260) diagnosed with a functional abdominal pain disorder (FAPD) from a previous trial assessing HT efficacy were approached for participation and 144 agreed to collect a buccal sample. Primary aim was to explore the association between COMT, OPRM1, and MAO-A polymorphisms with treatment success (TS) after 3-month HT. Additionally, associations between these polymorphisms and adequate relief, anxiety, depression, quality of life, somatization, hypnotic susceptibility, expectations, pain beliefs, and coping strategies were evaluated. Participants with different variations of COMT, MAO-A, and OPRM1 achieved similar TS levels (P > 0.05). No associations were found between these polymorphisms and secondary outcomes. This suggest that in pediatric patients with FAPDs, COMT, OPRM1, and MAO-A polymorphisms do not predict HT response.

Publisher

Wiley

Subject

Gastroenterology,Pediatrics, Perinatology and Child Health

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