B-Lymphoblastic Lymphoma in Children: A Case Series From a Single Institution-Reference-Cited by-同舟云学术

B-Lymphoblastic Lymphoma in Children: A Case Series From a Single Institution

Published:2024-02-16 Issue:3 Volume:46 Page:e254-e258
ISSN:1077-4114
Container-title:Journal of Pediatric Hematology/Oncology
language:en
Short-container-title:

Author:

Devine Kaitlin J.¹²,Trivedi Hirva¹,Reilly Anne F.¹²

Affiliation:

1. Division of Oncology, The Children’s Hospital of Philadelphia

2. Department of Pediatrics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA

Abstract

Background: Pediatric B-lymphoblastic lymphoma is an uncommon subtype of non-Hodgkin lymphoma. Studies regarding the biology, clinical course, and approach to relapse are limited. Observations: We present a series of children with B-lymphoblastic lymphoma to describe the clinical course at diagnosis and relapse as well as the role of tumor cytogenetics, immunotherapy, and hematopoietic stem cell transplant. Conclusions: The prognostic significance of cytogenetic changes in B-lymphoblastic lymphoma is not well described but may offer improved risk stratification. Immunotherapy may offer salvage options for relapsed disease and can serve as a bridge to transplant.

Publisher

Ovid Technologies (Wolters Kluwer Health)

Reference23 articles.

1. The impact of age and gender on biology, clinical features and treatment outcome of non-Hodgkin lymphoma in childhood and adolescence;Burkhardt;Br J Haematol,2005

2. Clinical presentation, evolution, and prognosis of precursor B-cell lymphoblastic lymphoma in trials LMT96, EORTC 58881, and EORTC 58951;Ducassou;Br J Haematol,2011

3. Genomic characterization of pediatric B-lymphoblastic lymphoma and B-lymphoblastic leukemia using formalin-fixed tissues;Meyer;Pediatr Blood Cancer,2017

4. Factors influencing survival after relapse from acute lymphoblastic leukemia: a Children’s Oncology Group study;Nguyen;Leukemia,2008

5. Outcome of newly diagnosed children and adolescents with localized lymphoblastic lymphoma treated on Children’s Oncology Group trial A5971: a report from the Children’s Oncology Group;Termuhlen;Pediatr Blood Cance,2012