Variable Clinical Courses of Varicella Zoster Virus Infection–related or Vaccination-related Bone Marrow Failure-Reference-Cited by-同舟云学术

Variable Clinical Courses of Varicella Zoster Virus Infection–related or Vaccination-related Bone Marrow Failure

Published:2024-04-23 Issue: Volume: Page:
ISSN:1077-4114
Container-title:Journal of Pediatric Hematology/Oncology
language:en
Short-container-title:

Author:

Toskov Vasil¹,Cseh Annamaria¹²,Claviez Alexander³,Drexler Beatrice¹⁴,Rotari Natalia¹,Schwarz-Furlan Stephan⁵⁶,Braun Matthias⁷,Bader Peter⁸,Lang Peter⁹,Beier Rita¹⁰,Erdlenbruch Bernhard¹¹,Führer Monika¹²,Erlacher Miriam¹,Niemeyer Charlotte M.¹,Strahm Brigitte¹,Yoshimi Ayami¹

Affiliation:

1. Department of Pediatrics and Adolescent Medicine, Division of Pediatric Hematology and Oncology, Medical Center, Faculty of Medicine, University of Freiburg, Freiburg

2. Department of Stem Cell Transplantation, St. Anna Children’s Hospital, Medical University of Vienna, Vienna, Austria

3. Department of Pediatrics, University Hospital Schleswig-Holstein, Campus Kiel, Kiel

4. Department of Medicine, Division of Hematology, University Hospital Basel, Basel, Switzerland

5. Institute of Pathology, Klinikum Kaufbeuren-Ravensburg, Kaufbeuren

6. Institute of Pathology, University Hospital Erlangen, Erlangen

7. Department of Padiatrische Hamatologie und Onkologie, Zentrum fur Kinderheiikunde der Justus-Liebig-Universitat Giessen, Giessen

8. Department for Children and Adolescents, Division for Stem Cell Transplantation and Immunology, University Hospital Frankfurt, Frankfurt am Main

9. Department of Hematology/Oncology and General Pediatrics, Children’s University Hospital, University of Tübingen, Tübingen

10. Department of Pediatric Hematology and Oncology, Hannover Medical School, Hannover

11. Department of Pediatrics, Johannes Wesling Klinikum Minden, Ruhr-University Bochum, Minden

12. Center for Pediatric Palliative Care, Dr von Hauner Children’s Hospital, University of Munich, Munich, Germany

Abstract

We report 5 children with bone marrow failure (BMF) after primary varicella zoster virus (VZV) infection or VZV vaccination, highlighting the highly variable course. Two patients were treated with intravenous immunoglobulins; one had a slow hematologic recovery, and the other was rescued by allogeneic hematopoietic stem cell transplantation (HSCT). Of the 2 patients treated with immunosuppressive therapy with antithymocyte globulin and cyclosporine, one had a complete response, and the other was transplanted for nonresponse. One patient underwent a primary allograft. All patients are alive. This study demonstrated that VZV-associated BMF is a life-threatening disorder that often requires HSCT.

Publisher

Ovid Technologies (Wolters Kluwer Health)

Reference20 articles.

1. Don’t forget how severe varicella can be—complications of varicella in children in a defined Polish population;Gowin;Int J Infect Dis,2013

2. Haematological complications in otherwise healthy children hospitalized for varicella;Elena;Vaccine,2011

3. Varicella disease among vaccinated persons: clinical and epidemiological characteristics, 1997–2005;Chaves;J Infect Dis,2008

4. Aplastic anemia following varicella vaccine;Angelini;Pediatric Infect Dis J,2009

5. Four year old child with breakthrough varicella leading to pancytopenia;Kakish;Bahrain Medical Bulletin,2009