The Effects of Extracorporeal Cardiopulmonary Resuscitation According to Covariate Adjustment

Author:

Ko Kwangchul1,Kim Yong Hwan1ORCID,Lee Jun Ho1ORCID,Lee Kyoung Yul2,Hwang Seong Youn1ORCID,Jin Mi Hyeon3

Affiliation:

1. Department of Emergency Medicine, Samsung Changwon Hospital, Sungkyunkwan University School of Medicine, Changwon, South Korea

2. Department of Physical Education, Kyungnam University, Changwon, South Korea

3. Department of Research Support, Samsung Changwon Hospital, Sungkyunkwan University School of Medicine, Changwon, South Korea.

Abstract

This study compared the effects of extracorporeal cardiopulmonary resuscitation (ECPR) using propensity-score matching (PSM) analyses. A nationwide registry of out-of-hospital cardiac arrest (OHCA) patients in Korea between 2013 and 2016 was used. Patients with OHCA aged ≥15 years with cardiac etiology and resuscitation time >30 minutes were enrolled. Resuscitation-related variables before the initiation of ECPR were included. Two PSM analyses were performed separately, with and without post-ECPR variables. The primary outcome (PO) was a favorable neurologic outcome at hospital discharge. The rate of PO was 8.1% (13/161) in the ECPR group and 1.5% (247/16,489) in the conventional CPR (CCPR) group. In the matched cohort with post-ECPR variables, there was no significant difference in the rate of PO between the ECPR and CCPR groups (7.9% vs. 7.9%; p = 0.982). In the matched cohort without post-ECPR variables, the rate of PO was higher in the ECPR group than that in the CCPR group (8.3% vs. 3.6%; p = 0.012). PSM analysis without post-ECPR variables compared outcomes of all patients experiencing OHCA and treated with ECPR versus CCPR, which showed better neurologic outcomes for ECPR. PSM analysis with post-ECPR variables compared outcomes between ECPR survivors and CCPR survivors, which exhibited similar neurologic outcomes.

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

Biomedical Engineering,General Medicine,Biomaterials,Bioengineering,Biophysics

Reference26 articles.

1. Association between cardiac arrest time and favorable neurological outcomes in witnessed out-of-hospital cardiac arrest patients treated with targeted temperature management.;Lee;J Korean Med Sci,2020

2. 2019 American Heart Association focused update on advanced cardiovascular life support: Use of advanced airways, vasopressors, and extracorporeal cardiopulmonary resuscitation during cardiac arrest: An update to the American Heart Association Guidelines for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care.;Panchal;Circulation,2019

3. Extracorporeal cardiopulmonary resuscitation for refractory out-of-hospital cardiac arrest: The state of the evidence and framework for application.;Grunau;Can J Cardiol,2018

4. Extracorporeal cardiopulmonary resuscitation in out-of-hospital cardiac arrest: A registry study.;Bougouin;Eur Heart J,2020

5. Comparison of extracorporeal and conventional cardiopulmonary resuscitation: A retrospective propensity score matched study.;Patricio;Crit Care,2019

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