An Unexpected Partnership: Alexis Carrel, Charles Lindbergh, and Normothermic Machine Perfusion

Author:

Cui Ervin Y.1,Gouchoe Doug A.12,Salmon-Rekhi Suhavi T.2,Whitson Bryan A.12,Black Sylvester M.123

Affiliation:

1. From the Division of Cardiac Surgery, Department of Surgery, Wexner Medical Center, The Ohio State University, Columbus, Ohio

2. Department of Surgery, The Collaboration for Organ Perfusion, Protection, Engineering and Regeneration Laboratory, The Ohio State University Wexner Medical Center, Columbus, Ohio

3. Department of Surgery, Comprehensive Transplant Center, The Ohio State University Wexner Medical Center, Columbus, Ohio.

Abstract

Organ transplantation is a triumph of modern medicine which represents a culmination of science and imagination, saving thousands of lives a year. However, transplantation is severely limited by suitable donor allografts. To expand the donor pool and make transplantation achievable for all, normothermic machine perfusion (NMP) is being employed more frequently. Normothermic machine perfusion involves the utilization of a device to approximate the physiology of the human body, preserve organs outside of the donor, and provide a dynamic assessment platform to determine organ suitability for transplantation. As NMP technology advances, it will soon be possible to genetically modify and actively repair these organs. Although its application to the field of transplantation is relatively new, the concept, foundation, and development of NMP can be traced back to the pioneering work of the surgeon-scientist, Alexis Carrel and the famous aviator, Charles Lindbergh in the 1930s. Their collaboration resulted in the Carrel–Lindbergh Perfusion device, an early perfusion device that was able to keep organs alive ex vivo for weeks and is most appropriately viewed as a precursor to modern machine perfusion technologies. As NMP technology becomes more advanced and refined, it is important to acknowledge the historical context in which these technologies emerged.

Publisher

Ovid Technologies (Wolters Kluwer Health)

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