1. Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University
2. Newcastle upon Tyne Hospitals NHS Foundation Trust
3. Population Health Sciences Institute, Newcastle University, Newcastle upon Tyne
4. Research Centre for Health and Life Sciences, Institute for Health and Wellbeing, Faculty of Health and Life Sciences, Coventry University, Coventry
5. Cardiothoracic Centre, Freeman Hospital, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK