Preoperative Workup of Patients With Excessive Central Airway Collapse

Abstract

Background: Tracheobronchoplasty (TBP) is a definitive anatomic intervention for patients with severe symptomatic expiratory central airway collapse. Although stent evaluations have been described for surgical workup, current literature does not address if improvement during stent evaluation is sustained after TBP. We compared health-related quality of life (HRQOL) and functional status responses after airway stenting to those post-TBP. Methods: A retrospective review was performed in patients with severe expiratory central airway collapse who underwent stent evaluation followed by TBP from January 2004 to December 2019. Baseline, poststent, 3- and 12-month postoperative HRQOL scores, and functional status were analyzed with statistical tests as appropriate. Results: One hundred twenty patients underwent a stent evaluation and TBP. Baseline and stent evaluation measurements were compared with statistically and clinically significant differences in the Cough Quality-of-life Questionnaire (CQLQ) (55 vs. 68, P<0.01), Modified Medical Research Council (mMRC) 0 to 2 (90% vs. 47%, P<0.01), 6-minute walk test (6MWT) (1301 ft vs. 1138 ft, P<0.01). Improvements in the HRQOL and functional status were maintained from stent evaluation to 3 months postoperatively [CQLQ 55 vs. 54, P=0.63; mMRC 0 to 2 (87% vs. 84%), P=0.39; 6MWT 1350 ft vs. 1314 ft, P=0.33], and 12 months postoperatively [CQLQ 54 vs. 54, P=0.91; mMRC 0 to 2 (95% vs. 86%), P=0.74; 6MWT 1409 ft vs. 1328 ft, P=0.13]. The magnitude of change between the data was not significantly different between the stent evaluation, 3-, and 12 months postoperative. Predicted forced expiratory volume in 1-second measurements at baseline, after stent placement, 3 months, and 12 months post-TBP were 74%, 79%, 73%, and 73%, respectively, and not clinically significant. Conclusions: Improvement after stent evaluation and the magnitude of improvement may be predictive of postoperative outcomes up to 1 year after surgery.