ABO blood type and functional neurological outcome in patients with severe traumatic brain injury

Author:

Esnault Pierre,Houcinat Nazim,de Malleray Hilaire,Quere Pierre-Louis,Cardinale Michael,D'aranda Erwan,Joubert Christophe,Dagain Arnaud,Goutorbe Philippe,Meaudre Eric

Abstract

BACKGROUND The ABO blood system has been involved in the pathogenesis of several diseases, including coagulopathy and bleeding complications. In trauma patients, blood type A has been associated with acute respiratory distress syndrome, and recently, blood type O has been associated with all-cause mortality. The purpose of this study was to assess the association between ABO blood types and long-term functional outcomes in critically ill patients with severe traumatic brain injury (TBI). METHODS We conducted a single-center, retrospective, observational study including all patients admitted to the intensive care unit with severe TBI (defined as a Glasgow Coma Scale score of ≤8) between January 2007 and December 2018. Patient characteristics and outcomes were extracted from a prospective registry of all intubated patients admitted to the intensive care unit for TBI. ABO blood types were retrospectively retrieved from patient medical records. The association between ABO blood type (A, B, AB, and O) and unfavorable functional outcome (defined by a Glasgow Outcome Scale score between 1 and 3) 6 months after injury was assessed in univariate and multivariate analysis. RESULTS A total of 333 patients meeting the inclusion criteria were included. There were 151 type O (46%), 131 type A (39%), 37 type B (11%), and 12 type AB patients (4%). No significant differences in baseline demographic, clinical, or biological characteristics were observed between blood types. The prevalence of unfavorable outcome was significantly different between the four groups. After adjustment for confounders, blood type O was significantly associated with unfavorable outcome at 6 months (odds ratio, 1.97; confidence interval [1.03–3.80]; p = 0.042). The prevalence of coagulopathy or progressive hemorrhagic injury was not statistically different between blood types (p = 0.575 and p = 0.813, respectively). CONCLUSION Blood type O appears to be associated with unfavorable long-term functional outcome in critically ill patients with severe TBI. Further studies are needed to detail the mechanism underlying this relationship. LEVEL OF EVIDENCE Prognostic and Epidemiological; Level IV.

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

Critical Care and Intensive Care Medicine,Surgery

Reference40 articles.

1. CDC grand rounds: reducing severe traumatic brain injury in the United States;MMWR Morb Mortal Wkly Rep,2013

2. Traumatic brain injury–related emergency department visits, hospitalizations, and deaths — United States, 2007 and 2013;MMWR Surveill Summ,2017

3. The ABO histo-blood group and AKI in critically ill patients with trauma or sepsis;Clin J Am Soc Nephrol,2015

4. ABO blood group influences risk of venous thromboembolism and myocardial infarction;J Thromb Thrombolysis,2020

5. ABO blood groups and hepatitis B virus infection: a systematic review and meta-analysis;BMJ Open,2020

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