Quantification of Tacrolimus and Three Demethylated Metabolites in Human Whole Blood Using LC–ESI

Quantification of Tacrolimus and Three Demethylated Metabolites in Human Whole Blood Using LC–ESI–MS/MS

Published:2012-04 Issue:2 Volume:34 Page:134-142
ISSN:0163-4356
Container-title:Therapeutic Drug Monitoring
language:en
Short-container-title:

Author:

Dubbelboer Ilse R.,Pohanka Anton,Said Rana,Rosenborg Staffan,Beck Olof

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

Pharmacology (medical),Pharmacology

Reference30 articles.

1. Metabolism of tacrolimus (FK506) and recent topics in clinical pharmacokinetics.;Iwasaki;Drug Metab Pharmacokinet,2007

2. Simultaneous determination of three isomeric metabolites of tacrolimus (FK506) in human whole blood and plasma using high performance liquid chromatography-tandem mass spectrometry.;Chen;J Chromatogr B Anal Technol Biomed Life Sci,2006

3. Effect of CYP3A5 polymorphism on tacrolimus metabolic clearance in vitro.;Dai;Drug Metab Dispos,2006

4. Tacrolimusa further update of its use in the management of organ transplantation.;Scott;Drugs,2003

5. Isolation, identification, and biological-activities of oxidative metabolites of Fk506, a potent immunosuppressive macrolide lactone.;Iwasaki;Drug Metab Dispos,1993

Cited by 38 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Tacrolimus Monitoring in Liver Transplant Recipients, Posttransplant Cholestasis: A Comparative Between 2 Commercial Immunoassays and a Liquid Chromatography-Tandem Mass Spectrometry Method;Therapeutic Drug Monitoring;2024-04-19

2. Determination of tacrolimus in human whole blood in kidney transplant recipients using a rapid and specific LC–MS/MS method;Journal of Clinical Laboratory Analysis;2023-08

3. Overview of therapeutic drug monitoring of immunosuppressive drugs: Analytical and clinical practices;Journal of Pharmaceutical and Biomedical Analysis;2021-10

4. Determination of tacrolimus, three mono-demethylated metabolites and a M1 tautomer in human whole blood by liquid chromatography – tandem mass spectrometry;Journal of Pharmaceutical and Biomedical Analysis;2021-10

5. Optimization and comparison of two microsampling approaches for LC-MS/MS analysis of a panel of immunosuppressants in blood samples;Sustainable Chemistry and Pharmacy;2021-06