Neighborhood Deprivation and Neural Tube Defects-Reference-Cited by-同舟云学术

Neighborhood Deprivation and Neural Tube Defects

Published:2023-09-26 Issue:6 Volume:34 Page:774-785
ISSN:1044-3983
Container-title:Epidemiology
language:en
Short-container-title:

Author:

Pruitt Evans Shannon¹²^ORCID,Ailes Elizabeth C.¹,Kramer Michael R.³,Shumate Charles J.⁴,Reefhuis Jennita¹,Insaf Tabassum Z.⁵⁶,Yazdy Mahsa M.⁷,Carmichael Suzan L.⁸,Romitti Paul A.⁹,Feldkamp Marcia L.¹⁰,Neo Dayna T.¹¹,Nembhard Wendy N.¹²,Shaw Gary M.⁸,Palmi Elizabeth¹¹³,Gilboa Suzanne M.¹,

Affiliation:

1. Division of Birth Defects and Infant Disorders, National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, GA

2. Eagle Global Scientific LLC, San Antonio, TX

3. Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA

4. Birth Defects Epidemiology and Surveillance Branch, Texas Department of State Health Services, Austin, TX

5. New York State Department of Health, Albany, NY

6. School of Public Health, University at Albany, Rensselaer, NY

7. Center for Birth Defects Research and Prevention, Massachusetts Department of Public Health, Boston, MA

8. Division of Neonatal and Developmental Medicine, Department of Pediatrics, Stanford University School of Medicine, Stanford, CA

9. Department of Epidemiology, College of Public Health, University of Iowa, Iowa City, IA

10. Division of Medical Genetics, Department of Pediatrics, University of Utah School of Medicine, Salt Lake City, UT

11. Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC

12. Department of Epidemiology, Fay W. Boozman College of Public Health, University of Arkansas for Medical Sciences, Little Rock, AR

13. Oak Ridge Institute for Science and Education, Oak Ridge, TN.

Abstract

Background: Individual measures of socioeconomic status (SES) have been associated with an increased risk of neural tube defects (NTDs); however, the association between neighborhood SES and NTD risk is unknown. Using data from the National Birth Defects Prevention Study (NBDPS) from 1997 to 2011, we investigated the association between measures of census tract SES and NTD risk. Methods: The study population included 10,028 controls and 1829 NTD cases. We linked maternal addresses to census tract SES measures and used these measures to calculate the neighborhood deprivation index. We used generalized estimating equations to calculate adjusted odds ratios (aORs) and 95% confidence intervals (CIs) estimating the impact of quartiles of census tract deprivation on NTDs adjusting for maternal race–ethnicity, maternal education, and maternal age at delivery. Results: Quartiles of higher neighborhood deprivation were associated with NTDs when compared with the least deprived quartile (Q2: aOR = 1.2; 95% CI = 1.0, 1.4; Q3: aOR = 1.3, 95% CI = 1.1, 1.5; Q4 (highest): aOR = 1.2; 95% CI = 1.0, 1.4). Results for spina bifida were similar; however, estimates for anencephaly and encephalocele were attenuated. Associations differed by maternal race–ethnicity. Conclusions: Our findings suggest that residing in a census tract with more socioeconomic deprivation is associated with an increased risk for NTDs, specifically spina bifida.

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

Epidemiology

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