HIV DNA positively correlates with HLA-DR+CD8+ T lymphocytes over 8-year suppressive antiretroviral therapy-Reference-Cited by-同舟云学术

HIV DNA positively correlates with HLA-DR+CD8+ T lymphocytes over 8-year suppressive antiretroviral therapy

Published:2023-04-20 Issue:8 Volume:37 Page:1335-1337
ISSN:0269-9370
Container-title:AIDS
language:en
Short-container-title:

Author:

Zhu Tianyuan¹,Cao Wei²,Li Taisheng²³

Affiliation:

1. Department of Medical Intensive Care Unit

2. Department of Infectious Diseases

3. State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China.

Abstract

We studied the relationship between HIV DNA and CD8+ T-cell activation in a retrospective cohort. We observed that the expression level of HLA-DR remained high in CD8+ T-cells and was positively correlated with total HIV DNA [odds ratio (OR) = 1.86, P = 0.028) during 8 years of suppressive antiretroviral therapy (ART). This study illustrated the long-term interplay between HIV DNA reservoir and host inflammatory state despite viral suppression.

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

Infectious Diseases,Immunology,Immunology and Allergy

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