A moving target: impacts of lowering viral load suppression cutpoints on progress towards HIV epidemic control goals-Reference-Cited by-同舟云学术

A moving target: impacts of lowering viral load suppression cutpoints on progress towards HIV epidemic control goals

Published:2023-05-03 Issue:9 Volume:37 Page:1486-1489
ISSN:0269-9370
Container-title:AIDS
language:en
Short-container-title:

Author:

Rosen Joseph G.¹,Reynolds Steven J.²³⁴,Galiwango Ronald M.²,Kigozi Godfrey²,Quinn Thomas C.²³⁴,Ratmann Oliver⁵,Ndyanabo Anthony²,Nelson Lisa J.⁶,Nakigozi Gertrude²,Nalugemwa Margaret²,Rucinski Katherine B.¹,Kennedy Caitlin E.¹²,Chang Larry W.¹²³,Kagaayi Joseph²,Serwadda David²,Grabowski M. Kate²⁷⁸

Affiliation:

1. Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA

2. Rakai Health Sciences Program, Entebbe, Uganda

3. Division of Infectious Diseases, Johns Hopkins School of Medicine, Baltimore

4. Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA

5. Department of Mathematics, Imperial College, London, UK

6. Centers for Disease Control and Prevention, Kampala, Uganda

7. Division of Pathology, Johns Hopkins School of Medicine

8. Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.

Abstract

Redefining viral load suppression (VLS) using lower cutpoints could impact progress towards the United Nations Programme on HIV/AIDS 95–95–95 targets. We assessed impacts of lowering the VLS cutpoint on achieving the ‘third 95’ in the Rakai Community Cohort Study. Population VLS would fall from 86% to 84% and 76%, respectively, after lowering VLS cutpoints from <1000 to <200 and <50 copies/ml. The fraction of viremic persons increased by 17% after lowering the VLS cutpoint from <1000 to <200 copies/ml.

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

Infectious Diseases,Immunology,Immunology and Allergy

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