Joint Fluid Cell Count in Acute Bacterial Arthritis Patients Proven Positive Culture in Children

Abstract

Background: Acute bacterial arthritis (ABA) is a serious, pediatric infection that can result in motor comorbidities. Normally, a joint fluid white blood cell (WBC) count of 50,000 or more cells/mm3 is used to make a presumptive diagnosis of ABA. This study evaluated the utility of the joint fluid WBC count for diagnosing pediatric ABA confirmed by a positive culture result. Methods: Patients with ABA between March 2010 and March 2023 at Tokyo Metropolitan Children’s Medical Center were included. ABA was confirmed by positive joint fluid culture results for a pathogenic organism. Patients with negative results and those without a joint fluid WBC count were excluded. Electronic medical records were retrospectively reviewed for demographic data, timing of arthrocentesis, culture results and the joint fluid WBC count. Results: Ninety-five patients with ABA were identified; of these, 22 were included. The median age was 5 years [interquartile range (IQR): 2–10 years]. Males comprised 55% of the population. The median joint fluid WBC count was 19,575 (IQR: 6806–47,388) cells/mm3, and 23% of the patients had 50,000 cells/mm3 or more. The median time from symptom onset to arthrocentesis was 3 days (IQR: 2–5 days). The isolated organisms were methicillin-susceptible Staphylococcus aureus (50%), methicillin-resistant S. aureus (9%), Streptococcus pyogenes (27%), Streptococcus pneumoniae (5%), Klebsiella pneumoniae (5%) and Salmonella spp. (5%). Conclusions: Most of the patients with ABA confirmed by positive results of a joint fluid culture had a joint fluid WBC count of less than 50,000 cells/mm3.