Strong correlation between F2RL3 in the blood and osteoarthritis based on a retrospective cohort study

Abstract

Osteoarthritis (OA) is a common joint disease that mainly damages articular cartilage and involves the whole joint tissue. The purpose of this study was to explore the relationship between F2R Like Thrombin Or Trypsin Receptor 3 (F2RL3) and OA, so as to provide a new direction for the treatment of bone and joint. A total of 234 patients with OA were recruited. Clinical data was recorded and the expression levels of ELOVL Fatty Acid Elongase 7, F2RL3, glycoprotein IX platelet and Integrin Subunit Alpha 2b were measured. Pearson chi-square test and Spearman correlation coefficient were used to analyze the relationship between OA and related parameters. Univariate and multivariate Logistic regression were used for further analysis. Pearson chi-square test showed that F2RL3 (P < .001) was significantly associated with OA; Spearman correlation coefficient showed that OA and F2RL3 (ρ = −0.511, P < .001) significantly correlated; Univariate Logistic regression analysis showed that F2RL3 (odds ratio = 0.104, 95% confidence interval: 0.057–0.189, P < .001) was significantly associated with OA; multivariate logistic regression analysis showed that F2RL3 (odds ratio = 0.098, 95% confidence interval: 0.053–0.182, P < .001) were significantly associated with OA. The expression of F2RL3 is low in patients with OA. The lower the expression of F2RL3, the higher the probability of OA.