Thrombospondin-2 acts as a critical regulator of cartilage regeneration: A review

Author:

Niu Jing12,Liu Yanli2,Wang Junjun2,Wang Hui2,Zhao Ying23,Zhang Min2ORCID

Affiliation:

1. The College of Life Sciences and Medicine, Northwest University, Xi’an, P. R. China

2. State Key Laboratory of Military Stomatology & National Clinical Research Center for Oral Disease, Department of General Dentistry and Emergency, School of Stomatology, Fourth Military Medical University, Xi’an, P. R. China

3. Department of Anesthesiology and Perioperative Medicine, Xi’an People’s Hospital (Xi’an Fourth Hospital), Northwest University, Xi’an, P. R. China.

Abstract

The degeneration of articular cartilage tissue is the most common cause of articular cartilage diseases such as osteoarthritis. There are limitations in chondrocyte self-renewal and conventional treatments. During cartilage regeneration and repair, growth factors are typically used to induce cartilage differentiation in stem cells. The role of thrombospondin-2 in cartilage formation has received much attention in recent years. This paper reviews the role of thrombospondin-2 in cartilage regeneration and the important role it plays in protecting cartilage from damage caused by inflammation or trauma and in the regenerative repair of cartilage by binding to different receptors and activating different intracellular signaling pathways. These studies provide new ideas for cartilage repair in clinical settings.

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

General Medicine

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