A case report of hypertrophic olivine degeneration complicated with OSAHS exacerbation: Case report and retrospective analysis

Author:

Geng Minxia12,Wang Lulu12,Xing Jiahao13,Li Shuang14,Dong Lulu14,Jiang Chao14,Wang Tianjun1ORCID

Affiliation:

1. Department of Neurology, Hebei General Hospital, Shijiazhuang, Hebei, China

2. Graduate School of North China University of Science and Technology, Tangshan, Hebei, China

3. Graduate School of Hebei Medical University, Shijiazhuang, Hebei, China

4. Graduate School of Hebei North University, Zhangjiakou, Hebei, China.

Abstract

Rationale: Hypertrophic subolivine degeneration (HOD) was destroyed by Guillain–Mollaret triangle (GMT) due to various injuries, resulting in anterograde cavity-like degeneration of the lower olive nucleus. In addition, the brain stem is related to the muscle coordination of the upper respiratory tract. Obstructive sleep apnea hypopnea syndrome may affect the respiratory center due to the injury of the brain stem. Brain stem hemorrhage damage GMT, resulting in transsynaptic neuronal degeneration. Clinical manifestations can be complex, and enhanced magnetic resonance imaging can be helpful in distinguishing them. Patient concerns: HOD is a self-limiting disease with no effective treatment and a long course of disease. Most patients can improve their symptoms after symptomatic treatment, and some patients can relieve their symptoms by themselves after 3 to 4 years. Diagnosis interventions: The limbs wobble involuntarily. His clinical symptoms and signs are consistent with HOD. Imaging with a clear primary lesion confirmed HOD. After treatment with antiepileptic drugs, the patient’s symptoms were relieved. Moreover, the patient had snoring and apnea, and respiratory sleep monitoring showed moderate obstructive sleep apnea hypopnea syndrome, which was treated with noninvasive ventilator. Outcomes: After treatment with antiepileptic drugs and noninvasive ventilator, the patient’s symptoms were significantly relieved. Lessons: HOD is a rare clinical disorder. Therefore, for similar patients, more attention should be paid to early diagnosis and treatment to avoid missed diagnosis, misdiagnosis and unnecessary intervention measures. The diagnosis can be confirmed by primary disease, clinical symptoms, and imaging based on GMT.

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

General Medicine

Reference8 articles.

1. Hypertrophic olivary degeneration: a case report.;Meltem;Indian J Radiol Imaging,2019

2. Deux cas de myocloniessynchrones et rhythmesvelo-ph aryngolayrngo-oculo-diaphragmatiques.;Guillain;Rev Neurol,1931

3. Olivary enlargement: chronological and morphometric analyses.;Goto;Acta Neuropathol,1981

4. Teaching NeuroImages: hemorrhagic cavernoma with secondary development of hypertrophic olivary degeneration.;Crosbie;Neurology,2013

5. Hypertrophic olivary degeneration on magnetic resonance imaging in mitochondrial syndromes associated with POLG and SURF1 mutations.;Kinghorn;J Neurol,2013

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