Affiliation:
1. Department of Thyroid and Breast Surgery, Hebei General Hospital Affiliated to Hebei North University, Shijiazhuang, China
2. Department of Thyroid and Breast Surgery, Hebei General Hospital Affiliated to North China University of Science and Technology, Shijiazhuang, China
3. Department of Thyroid and Breast Surgery, Hebei General Hospital Affiliated to Hebei Medicine University, Shijiazhuang, China
4. Department of Thyroid and Breast Surgery, Hebei General Hospital, Shijiazhuang, China.
Abstract
Objective:
To investigate the correlation of hypoxia-inducible factor-1α (HIF-1α) and hypoxia-inducible factor-2α (HIF-2α) protein expression with clinicopathologic characteristics in patients with papillary thyroid carcinoma (PTC) through a meta-analysis.
Methods:
PubMed, Embase, Web of Science, Cochrane, CNKI, Wanfang, and VIP databases were searched from the establishment of the database to February 2023. The New castle-Ottawa Scale was used to evaluate the quality of the literature. Rev Man 5.3 and Stata14.0 were used to conduct a meta-analysis of the included studies.
Results:
Twenty-eight articles with 2346 samples were included in the Meta-analysis. Compared with normal thyroid tissues, HIF-1α and HIF-2α proteins were highly expressed in PTC tumor tissues. High expression of HIF-1α protein was associated with tumor size (odds ratio [OR] = 4.50, 95% confidence interval [CI]: 2.88–7.04, P < .00001), lymph node metastasis (OR = 4.76, 95% CI: 3.78–5.99, P < .00001), TNM stage (OR = 3.67, 95% CI: 2.68–5.03, P < .00001), capsular invasion (OR = 2.30, 95% CI: 1.43–3.71, P = .0006 < .05), and extrathyroidal extension (OR = 10.96, 95% CI: 4.80–25.02, P < .00001). High expression of HIF-2α protein was associated with lymph node metastasis (OR = 4.18, 95% CI: 2.63–6.65, P < .00001), TNM stage (OR = 2.56, 95% CI: 1.36–4.82, P = .004 < .05), and capsular invasion (OR = 3.84, 95% CI: 1.66–8.88, P = .002 < .05). In addition, we concluded for the first time that there was a statistically significant difference in the expression of HIF-1α and HIF-2α in PTC patients (OR = 2.36, 95% CI: 1.26–4.42, P = .007 < .05).
Conclusions:
The high expression of HIF-1α and HIF-2α proteins is closely related to some clinicopathological parameters of PTC, and can provide potential biological indicators for the diagnosis and prognosis of PTC.
Publisher
Ovid Technologies (Wolters Kluwer Health)