Affiliation:
1. Affiliated Hospital of Hubei University of Chinese Medicine, Wuhan, China
2. Hubei Provincial Hospital of Traditional Chinese Medicine, Wuhan, China
3. Hubei Provincial Institute of Traditional Chinese Medicine, Wuhan, China.
Abstract
Background:
The purpose of this meta-analysis was to assess the effectiveness of botulinum toxin type A (BoNT-A) in reducing pain associated with fasciitis. By synthesizing the findings from multiple studies, we aimed to provide a comprehensive evaluation of the current evidence regarding the efficacy of BoNT-A in the treatment of fasciitis pain.
Methods:
To identify studies for our report, we conducted electronic database searches of Embase, PubMed, Web of Science, and the Cochrane Library from their inception to November 20, 2022. We included only randomized controlled trials that examined the therapeutic effects of BoNT-A on fasciitis pain, with the primary outcome measure being the visual analog scale. We conducted statistical analyses using RevMan 5.4 software.
Results:
Our final meta-analysis comprised 14 randomized controlled trials involving 537 participants, with 271 patients in the BoNT-A group and 266 patients in the control group. The overall effectiveness of BoNT-A in reducing fasciitis pain was significant, with a mean difference (MD) in visual analog scale score of −2.59 (95% confidence interval [CI], −3.36, −1.82); P < .00001; I
2 = 88%. Subgroup analysis revealed that BoNT-A was particularly effective in treating plantar fasciitis (MD = −3.34 [95% CI, −4.08, −2.78]; P < .00001; I
2 = 75%), lumbar back fasciitis (MD = −2.17 [95% CI, −3.82, −0.52]; P = .001; I
2 = 93%), and neck and shoulder fasciitis (MD = −1.49 [95% CI, −2.76, −0.22]; P = .02; I
2 = 61%).
Conclusion:
BoNT-A has a significant analgesic effect on fasciitis pain. Therefore, BoNT-A presents a promising alternative treatment option for fasciitis (PROSPERO 2022: CRD42022382805).
Publisher
Ovid Technologies (Wolters Kluwer Health)
Reference66 articles.
1. Deep fascia as a potential source of pain: a narrative review.;Weiss;J Bodyw Mov Ther,2021
2. Effectiveness of deep cervical fascial manipulation and yoga postures on pain, function, and oculomotor control in patients with mechanical neck pain: study protocol of a pragmatic, parallel-group, randomized, controlled trial.;Raja;Trials,2021
3. The deep fascia and its role in chronic pain and pathological conditions: a review.;Kondrup;Clin Anat,2022
4. Fibromyalgia: pathogenesis, mechanisms, diagnosis and treatment options update.;Siracusa;Int J Mol Sci,2021
5. Aponévropathie plantaire: mise au point 2021 [Plantar fasciitis: update 2021].;Muff;Rev Med Suisse,2021