Risk analysis of breast cancer and breast fibrocystic change in female primary Sjögren’s syndrome patients

Author:

Chen Hsin-Yu1,Chung Jui-Yuan23,Lin Shih-Chang345ORCID

Affiliation:

1. Department of Pediatrics, Hsinchu Cathay General Hospital, Hsinchu, Taiwan

2. Department of Emergency, Cathay General Hospital, Taipei, Taiwan

3. School of Medicine, School of Medicine, National Tsing Hua University, Hsinchu, Taiwan

4. Division of Rheumatology and Immunology, Department of Internal Medicine, Cathay General Hospital, Taipei, Taiwan

5. School of Medicine, Fu Jen Catholic University, New Taipei, Taiwan.

Abstract

Sjögren’s syndrome is an autoimmune disease with the chronic inflammation of glandular tissues, typically salivary and lacrimal glands. Since mammary tissue shares the glandular structure, Sjögren’s syndrome may also target mammary tissue to cause breast diseases. We therefore determined whether primary Sjögren’s syndrome (pSS) is associated with the increased risk of breast cancer (BC) and breast fibrocystic change (FC). Total 282 female patients with pSS were recruited from a medical center in Taiwan, and patients’ medical records were reviewed to identify BC and ultrasonographic breast FC. The prevalence, incidence and risk factors for BC and breast FC in pSS patients were determined, and the risk factors for these breast diseases were subsequently analyzed. Our results showed that pSS patients had the increased prevalence and incidence of BC, and high anti-SSA(Ro) antibody titers were found to be associated with the increased risk of BC. Breast FC was also found highly prevalent in these patients. Comorbidity analysis as risk factor for BC in pSS patients showed diabetes mellitus was strongly associated with the increased risk of BC (odds ratio = 10.4, P = .0006), whereas breast FC was inversely associated with the risk of BC (odds ratio = 0.077 P = .0158). These data indicated that pSS is association with the increased risk of BC and with the high prevalence of ultrasonographic breast FC. Our results also suggest that, in pSS patients, the high anti-SSA(Ro) antibody titers and diabetes mellitus confer the increased risk of BC, whereas the absence of ultrasonographic breast FC predicts the higher risk of BC.

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

General Medicine

Reference40 articles.

1. The epidemiology of Sjögren’s syndrome.;Patel;Clin Epidemiol,2014

2. Current aspects of pathogenesis in Sjögren’s syndrome.;Voulgarelis;Ther Adv Musculoskelet Dis,2010

3. Sjögren’s syndrome.;Fox;Lancet,2005

4. Primary Sjögren’s syndrome as a systemic disease: a study of participants enrolled in an international Sjögren’s syndrome registry.;Malladi;Arthritis Care Res. (Hoboken),2012

5. Sjögren’s syndrome: a systemic autoimmune disease.;Negrini;Clin Exp Med,2022

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3