The correlation of lymphocytes with disease progression of COVID-19

Author:

Chu Ming12,Zhao Xiaobao234,Tang Lu2345,Zhang Siwei2345,Zhang Shengkun1,Huang Dongdong1,Wang Fuxiang26,Wei Lanlan2345ORCID

Affiliation:

1. Department of Neurosurgery, The Third People’s Hospital of Shenzhen, Shenzhen, China

2. The Second Hospital Affiliated to Southern University of Science and Technology, Shenzhen, China

3. National Clinical Research Center for Infectious Diseases, Shenzhen, China

4. Institute for Hepatology, The Third People’s Hospital of Shenzhen, Shenzhen, China

5. Department of Microbiology, Harbin Medical University, Harbin, China

6. Department of Infectious Diseases, The Third People’s Hospital of Shenzhen, Shenzhen, China.

Abstract

The aim of this study is to evaluate the potential of lymphocytes as biomarkers to predict the decline of coronavirus disease 2019 (COVID-19). Lymphocytes were counted in 164 moderate COVID-19 patients in Shenzhen, China. Among the moderate infected patients, 12.2% (20/164) progressed to severe cases after admission. Compared with the stable patients, the counts of lymphocytes, both total T lymphocytes and CD4+ T lymphocytes, in the severe patients, were lower. The aggravation of moderate infected patients was significantly associated with lymphocyte count (hazard ratio [HR] = 0.91; 95% confidence interval [CI]: 0.84–0.99), total T lymphocyte count (HR = 0.91; 95% CI: 0.84–0.99), and CD4+ T lymphocyte count (HR = 0.91; 95% CI: 0.85–0.98). Total T lymphocytes and CD4+ T lymphocytes could be important biomarkers to evaluate the risk of aggravation for moderate infected COVID-19 patients. The patients with low percentages of total T lymphocytes and CD4+ T lymphocytes need more attention.

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

General Medicine

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