Is CaMKII friend or foe for cell apoptosis in eye?: A narrative review-Reference-Cited by-同舟云学术

Is CaMKII friend or foe for cell apoptosis in eye?: A narrative review

Published:2023-12-01 Issue:48 Volume:102 Page:e36136
ISSN:0025-7974
Container-title:Medicine
language:en
Short-container-title:

Author:

Xu Weixing¹²,Liu Hua¹³^ORCID

Affiliation:

1. School of Graduate, Dalian Medical University, Dalian, China

2. The Third Affiliated Hospital of Jinzhou Medical University, Jinzhou, China

3. School of Graduate, Jinzhou Medical University, Jinzhou, China.

Abstract

Ca2+/calmodulin-dependent protein kinase II (CaMKII) controls cell proliferation, differentiation, apoptosis, and other biological processes that have an essential role in eye diseases. However, it seems that previous studies have generated conflicting conclusions about the effect of CaMKII on cell apoptosis. In this review, we explore the positive and potentially deleterious effects of CaMKII on eye cell apoptosis. We can safely conclude that the early elevation of CaMKII could be viewed as a promoter of cell apoptosis. Overexpression of CaMKII by transfection or pretreatment with drugs helped combat cell apoptosis.

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

General Medicine

Reference35 articles.

1. The versatility and universality of calcium signalling.;Berridge;Nat Rev Mol Cell Biol,2000

2. Preservation of vision after CaMKII-mediated protection of retinal ganglion cells.;Guo;Cell,2021

3. Neuronal CA2+/calmodulin-dependent protein kinase II: the role of structure and autoregulation in cellular function.;Hudmon;Annu Rev Biochem,2002

4. Selective blockade of CaMKII-alpha inhibits NMDA-induced caspase-3-dependent cell death but does not arrest PARP-1 activation or loss of plasma membrane selectivity in rat retinal neurons.;Goebel;Brain Res,2009

5. Neuroprotective effect of AIP on N-methyl-D-aspartate-induced cell death in retinal neurons.;Laabich;Brain Res Mol Brain Res,2000