The potential role of serum lipoprotein in children with sepsis

Abstract

To determine whether serum lipoprotein is correlated with sepsis on the day of admission and help with early warning, identification, and intervention for sepsis. This retrospective study involved all children admitted to our pediatric intensive care unit from January 2021 to June 2023. Clinical data of involved patients were collected via inquiring databases of our hospital. The Pediatric Risk of Mortality and Pediatric Index of Mortality II scores were calculated, multivariate analysis was conducted to evaluate the independence of the association between serum lipoprotein and the risk of sepsis on the day of admission. This study involved 88 children (48 with sepsis, 40 non-sepsis). The sepsis group had a lower level of high-density lipoprotein (HDL), total cholesterol, and low-density lipoprotein (LDL). The CRP, white blood cell, and procalcitonin (PCT) were considerably higher than the non-sepsis group. After adjusting for covariates, logistic regression analysis suggested that the CRP, PCT, HDL, Pediatric Risk of Mortality score, Pediatric Index of Mortality II score and LDL were independent risk factors for sepsis. Moreover, the AUC of CRP, PCT, HDL, and LDL were 0.58, 0.76, 0.82, and 0.86, respectively. Our results may indicate that serum lipoprotein is correlated with sepsis on the day of admission and may help with early warning, identification, and intervention for sepsis.