Salivary and serum levels of lactate dehydrogenase in oral submucous fibrosis: A meta-analysis

Author:

Chen Xueru1,Chen Tongqiang2,Xie Hui1,Guo Jincai1ORCID

Affiliation:

1. Department of Pharmacy, Changsha Stomatological Hospital, Changsha, China

2. Hunan Provincial Institute of Product and Goods Quality Inspection, Changsha, China.

Abstract

Background: The occurrence of oral submucous fibrosis (OSF) is often accompanied by an increase in lactate dehydrogenase (LDH) levels. In this meta-analysis, we compared the salivary and serum levels of LDH levels between OSF patients and controls. Material and methods: A comprehensive search was conducted in PubMed, Embase, Web of Science, and Cochrane Library from the establishment of the database to June 2023, and the quality of the studies was checked by the Newcastle-Ottawa Quality Assessment scale. The mean difference (MD) and 95% confidence interval (CI) were calculated using RevMan 5.4 software. Results: A total of 28 studies were retrieved from the database, and we included 5 studies in this meta-analysis. The salivary LDH level of OSF patients was higher than healthy controls (MD: 423.10 pg/L 95%CI: 276.42−569.77 pg/mL, P < .00001), the serum LDH level of OSF patients was also higher than that of healthy controls (MD: 226.20 pg/mL, 95%CI: 147.71−304.69 pg/mL, P < .00001). Conclusions: This meta-analysis showed that salivary and serum LDH levels were higher in OSF patients than in healthy controls, suggesting that LDH may be a potential biomarker for OSF.

Publisher

Ovid Technologies (Wolters Kluwer Health)

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