Late onset neonatal sepsis: Can plasma gelsolin be a promising diagnostic marker?-Reference-Cited by-同舟云学术

Late onset neonatal sepsis: Can plasma gelsolin be a promising diagnostic marker?

Published:2024-03-08 Issue:10 Volume:103 Page:e37356
ISSN:0025-7974
Container-title:Medicine
language:en
Short-container-title:

Author:

Mokhtar Wesam A.¹,Sherief Laila M.¹,Kamal Naglaa M.²,ElSheikh Azza O.³,Omran Farida H.³,Abdulsaboor Ahmed⁴,Sakr Maha M.H.⁴,El Gebally Shreif¹,Shehab Mohamed M. M.¹,Alfaifi Jaber⁵,Turkistani Reem⁶,Aljuaid Futun⁷,Oshi Mohammed A.M.⁸,Elbekoushi Fouad B.A.⁹,Mokhtar Ghada A.³

Affiliation:

1. Pediatric Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt

2. Pediatric Department, Faculty of Medicine, Cairo University, Giza, Egypt

3. Medical Microbiology and Immunology Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt

4. Clinical Pathology Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt

5. Department of Child Health, Faculty of Medicine, University of Bisha, Bisha, Kingdom of Saudi Arabia

6. Pediatric Department, Alhada Armed Forces Hospital, Taif, Kingdom of Saudi Arabia

7. Pediatric Department, Taif Children Hospital, Taif, Kingdom of Saudi Arabia

8. Neurology Division, Pediatric Department, Gaafar Ibnauf Children’s Emergency Hospital, Khartoum, Sudan

9. Pediatric Department, Zagazig University, Zagazig, Egypt.

Abstract

Plasma gelsolin (pGSN) correlates with clinical improvement in septic patients. We aimed to investigate pGSN levels as a diagnostic and prognostic marker of neonatal late-onset-sepsis (LOS). A case-control study was done on 184 neonates (92 with LOS and 92 controls). All participants were subjected to detailed history taking, full clinical evaluation, sepsis workup, and pGSN enzyme-linked immunosorbent-assay measurement. We detected significantly lower pGSN level among cases compared to controls (90.63 ± 20.64 vs 451.83 ± 209.59). It was significantly related to the severity of sepsis and mortality, with significantly lower values among cases with septic shock and multiorgan failure and non-survivors. Follow-up pGSN significantly increased after sepsis improvement in survivors compared to admission values. pGSN might be a reliable diagnostic and prognostic marker for LOS.

Publisher

Ovid Technologies (Wolters Kluwer Health)

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