Subcutaneous Administration of Carbidopa Enhances Oral Levodopa Pharmacokinetics: A Series of Studies Conducted in Pigs, Mice, and Healthy Volunteers

Author:

Shaltiel-Karyo Ronit,Caraco Yoseph,Zawaznik Eduardo,Weinstock Irena,Nemas Mara,Oren Sheila,Yacoby-Zeevi Oron,LeWitt Peter A.

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

Pharmacology (medical),Neurology (clinical),Pharmacology

Reference23 articles.

1. The site of dopamine formation in rat striatum after L-dopa administration;J Pharmacol Exp Ther,1981

2. Central levodopa metabolism in Parkinson's disease after administration of stable isotope-labeled levodopa;Ann Neurol,1997

3. Carbidopa in Parkinson disease and in nausea and vomiting of levodopa;Arch Neurol,1974

4. Inhibition of decarboxylase and levels of dopa and 3-O-methyldopa: a comparative study of benserazide versus carbidopa in rodents and of Madopar standard versus Madopar HBS in volunteers;Eur Neurol,1987

5. The effect of carbidopa on the pharmacokinetics of intravenously administered levodopa: the mechanism of action in the treatment of parkinsonism;Ann Neurol,1985

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