Heterogenous MSH6 Loss Is a Result of Microsatellite Instability Within MSH6 and Occurs in Sporadic and Hereditary Colorectal and Endometrial Carcinomas

Author:

Graham Rondell P.,Kerr Sarah E.,Butz Malinda L.,Thibodeau Stephen N.,Halling Kevin C.,Smyrk Thomas C.,Dina Michelle A.,Waugh Victoria M.,Rumilla Kandelaria M.

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

Pathology and Forensic Medicine,Surgery,Anatomy

Reference16 articles.

1. . Secondary mutation in a coding mononucleotide tract in MSH6 causes loss of immunoexpression of MSH6 in colorectal carcinomas with MLH1PMS2 deficiency.;Shia;Mod Pathol,2013

2. . Immunohistochemistry versus microsatellite instability testing in phenotyping colorectal tumors.;Lindor;J Clin Oncol,2002

3. Heredity and adenocarcinoma of the colon.;Lynch;Gastroenterology,1967

4. Clinical description of the Lynch syndrome (hereditary nonpolyposis colorectal cancer HNPCC).;Vasen;Fam Cancer,2005

5. . Altered expression of hMSH2 and hMLH1 in tumors with microsatellite instability and genetic alterations in mismatch repair genes.;Thibodeau;Cancer Res,1996

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