Abstract
Purpose of review
Explore whether immunization with germline-targeting Env immunogens during ART, followed by ATI, leads to the identification of viral envelope glycoproteins (Envs) that promote and guide the full maturation of broadly neutralizing antibody responses.
Recent findings
The HIV-1 envelope glycoprotein (Env) does not efficiently engage the germline precursors of broadly neutralizing antibodies (bnAbs). However, Env-derived proteins specifically designed to precisely do that, have been recently developed. These ‘germline-targeting’ Env immunogens activate naïve B cells that express the germline precursors of bnAbs but by themselves cannot guide their maturation towards their broadly neutralizing forms. This requires sequential immunizations with heterologous sets of Envs. These ‘booster’ Envs are currently unknown.
Summary
Combining germline-targeting Env immunization approaches during ART with ATI could lead to the identification of natural Envs that are responsible for the maturation of broadly neutralizing antibody responses during infection. Such Envs could then serve as booster immunogens to guide the maturation of glBCRs that have become activated by germline-targeting immunogens in uninfected subjects.
Publisher
Ovid Technologies (Wolters Kluwer Health)
Subject
Virology,Infectious Diseases,Oncology (nursing),Oncology,Hematology,Immunology
Cited by
2 articles.
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1. Human Immunodeficiency Virus Vaccine;Infectious Disease Clinics of North America;2024-09
2. Is an HIV vaccine still achievable?;Current Opinion in HIV and AIDS;2023-10-05