Refining Auxiliary Orthotopic Liver Transplantation (AOLT) Improves Outcomes in Adult Patients with Acute Liver Failure

Abstract

Objective: To investigate whether and how experience accumulation and technical refinements simultaneously implemented in auxiliary orthotopic liver transplantation (AOLT) may impact on outcomes. Background: AOLT for acute liver failure(ALF) provides the unique chance of complete immunosuppression withdrawal after adequate native liver remnant regeneration, but is a technically demanding procedure. Our department is a reference center for ALF and an early adopter of AOLT. Methods: This is a single center retrospective before/after study of a prospectively-maintained cohort of 48 patients with ALF who underwent AOLT between 1993 and 2019. In 2012 technical refinements were implemented to improve outcomes: (i)favoring the volume of the graft rather than that of the native liver, (ii)direct anastomosis of graft hepatic artery with recipient right hepatic artery instead of the use of large size vessels, (iii)end-to-side hepatico-choledocostomy instead of bilio-enteric anastomosis. Early experience(1993-2011) group(n=26) and recent experience(2012-2019) group(n=22) were compared. Primary endpoint was 90-day severe morbidity rate (Clavien-Dindo≥IIIa) and secondary endpoints were overall patient survival and complete immunosuppression withdrawal rates. Results: Compared with the earlier experience group, the recent experience group was associated witha lower severe complication rate (27% vs. 65%,P<0.001), as well as less biliary (18% vs. 54%,P=0.017) and arterial (0% vs. 15%,P=0.115) complications. The 1-, 3- and 5-year patient survival was significantly improved(91%, 91%, 91% vs. 76%, 61%, 60%,P=0.045). The rate of complete immunosuppression withdrawal increased to 94% (vs. 70%,P=0.091) with no need of long-term graft explant. Conclusions: These technical refinements favoringthe liver graftand reducing morbidity may promote AOLT implementation among LT centers.