Multimodal Imaging Evaluation of Rabbit Models

Abstract

Currently available imaging modalities each have limitations in their scope, preventing a comprehensive view of the eye. A multimodal system can simultaneously use numerous modalities to increase the effectiveness of imaging to provide structural and functional information, while decreasing the time and invasiveness of multiple procedures. In this study, optical coherence tomography (OCT), photoacoustic microscopy (PAM), fundus photography, fluorescein angiography (FA), and indocyanine green angiography (ICGA) were performed on a baseline rabbit model to verify the imaging system. Clear images distinguishing retinal vessels, choroidal vessels, and retinal layers were obtained, verifying the multimodal system’s efficacy before imaging experimental models. Imaging macular degeneration and glaucoma animal models can advance understanding of novel treatments in ophthalmic research. Multimodal imaging also offers a promising new means for early detection of retinal diseases in clinical settings.