Nonhuman primates exposed to Zika virus in utero are not protected against reinfection at 1 year postpartum

Author:

Vannella Kevin M.12ORCID,Stein Sydney12ORCID,Connelly Mark12,Swerczek Joanna3ORCID,Amaro-Carambot Emerito4,Coyle Elizabeth M.5,Babyak Ashley12,Winkler Clayton W.6ORCID,Saturday Greg7,Gai Neville D.8,Hammoud Dima A.8,Dowd Kimberly A.9ORCID,Valencia Luis Perez12ORCID,Ramos-Benitez Marcos J.12,Kindrachuk Jason1210ORCID,Pierson Theodore C.9ORCID,Peterson Karin E.6ORCID,Brenchley Jason M.11,Whitehead Steve S.4ORCID,Khurana Surender5ORCID,Herbert Richard3,Chertow Daniel S.12ORCID

Affiliation:

1. Emerging Pathogens Section, Critical Care Medicine Department, Clinical Center, National Institutes of Health, Bethesda, MD 20892, USA.

2. Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

3. Experimental Primate Virology Section, Comparative Medicine Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Poolesville, MD 20837, USA.

4. Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

5. Division of Viral Products, Center for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, MD 20993, USA.

6. Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA.

7. Rocky Mountain Veterinary Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA.

8. Center for Infectious Disease Imaging, Radiology and Imaging Services, National Institutes of Health, Bethesda, MD 20892, USA.

9. Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

10. Laboratory of Emerging Viruses, Department of Medical Microbiology, University of Manitoba, Winnipeg, MB R3E 0J9, Canada.

11. Barrier Immunity Section, Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

Abstract

Macaques exposed to Zika virus in utero mount a Zika virus–specific immune response that is not protective against reinfection 1 year after birth.

Funder

Division of Intramural Research, National Institute of Allergy and Infectious Diseases

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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