RNA-seq of human T cells after hematopoietic stem cell transplantation identifies Linc00402 as a regulator of T cell alloimmunity

Author:

Peltier Daniel1ORCID,Radosevich Molly1ORCID,Ravikumar Visweswaran2ORCID,Pitchiaya Sethuramasundaram3ORCID,Decoville Thomas1,Wood Sherri C.4,Hou Guoqing5,Zajac Cynthia5ORCID,Oravecz-Wilson Katherine5ORCID,Sokol David5,Henig Israel5,Wu Julia5ORCID,Kim Stephanie5ORCID,Taylor Austin5,Fujiwara Hideaki5,Sun Yaping5,Rao Arvind2,Chinnaiyan Arul M.6ORCID,Goldstein Daniel R.7ORCID,Reddy Pavan5ORCID

Affiliation:

1. Division of Hematology and Oncology, Department of Pediatrics, University of Michigan, Ann Arbor, MI 48109, USA.

2. Departments of Computational Medicine and Bioinformatics, Biostatistics, Radiation Oncology, and Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109, USA.

3. Michigan Center for Translational Pathology, University of Michigan, Ann Arbor, MI 48109, USA.

4. Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA.

5. Division of Hematology and Oncology, Department of Internal Medicine, University of Michigan Rogel Cancer Center, Ann Arbor, MI 48109, USA.

6. Department of Pathology, Michigan Center for Translational Pathology, Howard Hughes Medical Institute, University of Michigan, Ann Arbor, MI 48109, USA.

7. Department of Internal Medicine, Institute of Gerontology, and Department of Microbiology and Immunology, Program of Michigan Biology of Cardiovascular Aging, University of Michigan, Ann Arbor, MI 48109, USA.

Abstract

LncRNAs are differentially expressed by allogeneic antigen-stimulated T cells, and Linc00402 regulates allogeneic T cells.

Funder

NIH Office of the Director

Vetenskapsrådet

St. Baldrick’s Foundation

Hyundai Hope On Wheels

FUNDING

NCI SPORE Career Anhancement Award

PCF Young Investigator Award

Department of Defense Idea Development Award

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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