Aβ-accelerated neurodegeneration caused by Alzheimer’s-associated ACE variant R1279Q is rescued by angiotensin system inhibition in mice-Reference-Cited by-同舟云学术

Aβ-accelerated neurodegeneration caused by Alzheimer’s-associated ACE variant R1279Q is rescued by angiotensin system inhibition in mice

Published:2020-09-30 Issue:563 Volume:12 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Cuddy Leah K.¹^ORCID,Prokopenko Dmitry²^ORCID,Cunningham Eric P.¹^ORCID,Brimberry Ross¹,Song Peter¹^ORCID,Kirchner Rory³^ORCID,Chapman Brad A.³,Hofmann Oliver⁴^ORCID,Hide Winston⁵^ORCID,Procissi Daniele⁶^ORCID,Hanania Taleen⁷^ORCID,Leiser Steven C.⁷,Tanzi Rudolph E²^ORCID,Vassar Robert¹⁸^ORCID

Affiliation:

1. Ken and Ruth Davee Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.

2. Genetics and Aging Unit and McCance Center for Brain Health, Department of Neurology, Massachusetts General Hospital, Boston, MA 02129, USA.

3. Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA.

4. Department of Clinical Pathology, University of Melbourne, Victoria 3000, Melbourne, Australia.

5. Department of Pathology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA.

6. Department of Radiology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.

7. PsychoGenics Inc., Paramus, NJ 07652, USA.

8. Mesulam Center for Cognitive Neurology and Alzheimer’s Disease, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.

Abstract

Ace1 knockin mice have increased neuronal ACE1 and hippocampal neuron loss that is accelerated by Aβ and blocked by approved angiotensin pathway drugs.

Funder

National Institutes of Health

JPB Foundation

Cure Alzheimer’s Fund

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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