Genome-encoded cytoplasmic double-stranded RNAs, found in C9ORF72 ALS-FTD brain, propagate neuronal loss-Reference-Cited by-同舟云学术

Genome-encoded cytoplasmic double-stranded RNAs, found in C9ORF72 ALS-FTD brain, propagate neuronal loss

Published:2021-07-07 Issue:601 Volume:13 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Rodriguez Steven¹²^ORCID,Sahin Asli¹^ORCID,Schrank Benjamin R.¹^ORCID,Al-Lawati Hawra¹^ORCID,Costantino Isabel¹^ORCID,Benz Eric¹,Fard Darian¹^ORCID,Albers Alefiya D.¹³^ORCID,Cao Luxiang¹,Gomez Alexis C.¹^ORCID,Evans Kyle¹²^ORCID,Ratti Elena¹^ORCID,Cudkowicz Merit¹^ORCID,Frosch Matthew P.⁴^ORCID,Talkowski Michael¹⁵^ORCID,Sorger Peter K.²^ORCID,Hyman Bradley T.¹^ORCID,Albers Mark W.¹²^ORCID

Affiliation:

1. Department of Neurology, Massachusetts General Hospital, Boston, MA 02129, USA.

2. Laboratory of Systems Pharmacology, Department of Systems Biology, Harvard Program in Therapeutic Science, Harvard Medical School, Boston, MA 02115, USA.

3. Department of Psychology, Endicott College, Beverly, MA 01915, USA.

4. Department of Pathology, Massachusetts General Hospital, Boston, MA 02114, USA.

5. Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA 02114, USA.

Abstract

Genome-encoded cytoplasmic double-stranded RNAs elicit neuroinflammation and propagated neuronal death.

Funder

National Institutes of Health

National Institute on Aging

National Institute of Neurological Disorders and Stroke

Coins for Alzheimer’s Research Trust

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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