Single-cell transcriptional landscapes reveal HIV-1–driven aberrant host gene transcription as a potential therapeutic target-Reference-Cited by-同舟云学术

Single-cell transcriptional landscapes reveal HIV-1–driven aberrant host gene transcription as a potential therapeutic target

Published:2020-05-13 Issue:543 Volume:12 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Liu Runxia¹^ORCID,Yeh Yang-Hui Jimmy¹^ORCID,Varabyou Ales²^ORCID,Collora Jack A.¹^ORCID,Sherrill-Mix Scott³^ORCID,Talbot C. Conover⁴^ORCID,Mehta Sameet⁵^ORCID,Albrecht Kristen¹^ORCID,Hao Haiping⁴^ORCID,Zhang Hao⁶,Pollack Ross A.⁷,Beg Subul A.⁷^ORCID,Calvi Rachela M.⁸,Hu Jianfei⁹,Durand Christine M.⁷^ORCID,Ambinder Richard F.⁷^ORCID,Hoh Rebecca¹⁰^ORCID,Deeks Steven G.¹⁰^ORCID,Chiarella Jennifer⁸,Spudich Serena⁸,Douek Daniel C.⁹,Bushman Frederic D.³^ORCID,Pertea Mihaela²¹¹,Ho Ya-Chi¹^ORCID

Affiliation:

1. Department of Microbial Pathogenesis, Yale University School of Medicine, New Haven, CT 06519, USA.

2. Department of Computer Science, Whiting School of Engineering, Johns Hopkins University, Baltimore, MD 21218, USA.

3. Department of Microbiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA.

4. Institute for Basic Biomedical Sciences, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA.

5. Yale Center for Genome Analysis, Yale University, New Haven, CT 06519, USA.

6. Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA.

7. Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

8. Department of Neurology, Yale University School of Medicine, New Haven, CT 06519, USA.

9. Vaccine Research Center, National Institute of Health, Bethesda, MD 20892, USA.

10. Department of Medicine, University of California, San Francisco, CA 94110, USA.

11. Department of Biomedical Engineering, Whiting School of Engineering, Johns Hopkins University, Baltimore, MD 21218, USA.

Abstract

Single-cell transcriptome analysis by HIV-1 SortSeq identifies HIV-1–driven aberrant host gene transcription as a mechanism of HIV-1 persistence.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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