The mitochondrial peptidase, neurolysin, regulates respiratory chain supercomplex formation and is necessary for AML viability-Reference-Cited by-同舟云学术

The mitochondrial peptidase, neurolysin, regulates respiratory chain supercomplex formation and is necessary for AML viability

Published:2020-04-08 Issue:538 Volume:12 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Mirali Sara¹²^ORCID,Botham Aaron¹³,Voisin Veronique⁴,Xu Changjiang⁴,St-Germain Jonathan¹^ORCID,Sharon David¹^ORCID,Hoff Fieke W.⁵⁶,Qiu Yihua⁶^ORCID,Hurren Rose¹,Gronda Marcela¹,Jitkova Yulia¹,Nachmias Boaz¹^ORCID,MacLean Neil¹,Wang Xiaoming¹,Arruda Andrea¹,Minden Mark D.¹²³^ORCID,Horton Terzah M.⁷,Kornblau Steven M.⁶^ORCID,Chan Steven M.¹³,Bader Gary D.⁴⁸^ORCID,Raught Brian¹³^ORCID,Schimmer Aaron D.¹²³^ORCID

Affiliation:

1. Princess Margaret Cancer Centre, Toronto, Ontario M5G 1L7, Canada.

2. Institute of Medical Science, University of Toronto, Toronto M5S 1A8, Ontario, Canada.

3. Department of Medical Biophysics, University of Toronto, Toronto M5G 1L7, Ontario, Canada.

4. Donnelly Centre for Cellular and Biomolecular Research, Toronto, Ontario M5S 3E1, Canada.

5. Department of Pediatric Oncology/Hematology, University Medical Center Groningen, Groningen 9700 RB, Netherlands.

6. Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.

7. Texas Children's Cancer and Hematology Centers, Baylor College of Medicine, Houston, TX 77030, USA.

8. Department of Molecular Genetics, University of Toronto, Toronto M5S 1A8, Ontario, Canada.

Abstract

Targeting mitochondrial supercomplex assembly impairs metabolism and selectively targets leukemic cells.

Funder

National Institutes of Health

Princess Margaret Cancer Foundation

Ontario Institute for Cancer Research

Canadian Cancer Society Research Institute

Canadian Institutes of Health Research

Ontario Ministry of Health and Long-Term Care

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference52 articles.

1. Inhibition of the Mitochondrial Protease ClpP as a Therapeutic Strategy for Human Acute Myeloid Leukemia

2. Venetoclax with azacitidine disrupts energy metabolism and targets leukemia stem cells in patients with acute myeloid leukemia

3. Inhibition of Mitochondrial Translation as a Therapeutic Strategy for Human Acute Myeloid Leukemia

4. AML cells have low spare reserve capacity in their respiratory chain that renders them susceptible to oxidative metabolic stress

5. Proteolytic control of mitochondrial function and morphogenesis

Cited by 37 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Structural basis of divergent substrate recognition and inhibition of human neurolysin;Scientific Reports;2024-08-08

2. Mitochondrial proteases modulate mitochondrial stress signalling and cellular homeostasis in health and disease;Biochimie;2024-06

3. The Role of Oxidative Metabolism in Tumorigenesis and Drug Resistance;Discovery Medicine;2024

4. Landscape of molecular crosstalk between SARS-CoV-2 infection and cardiovascular diseases: emphasis on mitochondrial dysfunction and immune-inflammation;Journal of Translational Medicine;2023-12-16

5. Integrated bioinformatic analysis of mitochondrial metabolism-related genes in acute myeloid leukemia;Frontiers in Immunology;2023-04-17