Persistently activated, proliferative memory autoreactive B cells promote inflammation in rheumatoid arthritis-Reference-Cited by-同舟云学术

Persistently activated, proliferative memory autoreactive B cells promote inflammation in rheumatoid arthritis

Published:2020-11-18 Issue:570 Volume:12 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Kristyanto Hendy¹^ORCID,Blomberg Nienke J.¹,Slot Linda M.¹,van der Voort Ellen I. H.¹,Kerkman Priscilla F.¹²^ORCID,Bakker Aleida¹,Burgers Leonie E.¹,ten Brinck Robin M.¹^ORCID,van der Helm-van Mil Annette H. M.¹,Spits Hergen³⁴^ORCID,Baeten Dominique L.⁵⁶,Huizinga Tom W. J.¹^ORCID,Toes René E. M.¹^ORCID,Scherer Hans U.¹^ORCID

Affiliation:

1. Department of Rheumatology, Leiden University Medical Center, 2300RC Leiden, Netherlands.

2. Department of Medical Microbiology, University Medical Center Utrecht, 3584CX Utrecht, Netherlands.

3. Department of Experimental Immunology and Amsterdam Institute of Infection and Immunity, Amsterdam University Medical Center, location AMC, 1105AZ Amsterdam, Netherlands.

4. AIMM Therapeutics, 1045BA Amsterdam, Netherlands.

5. Department of Clinical Immunology and Rheumatology, Amsterdam University Medical Center, location AMC, 1105AZ Amsterdam, Netherlands.

6. UCB Pharma, 1070 Brussels, Belgium.

Abstract

Proliferative autoreactive B cells secreting proinflammatory cytokines are associated with early, untreated RA and persist in established disease.

Funder

H2020 European Research Council

Nederlandse Organisatie voor Wetenschappelijk Onderzoek

Innovative Medicines Initiative

Dutch arthritis foundation

Publisher

American Association for the Advancement of Science (AAAS)