Glycine-based treatment ameliorates NAFLD by modulating fatty acid oxidation, glutathione synthesis, and the gut microbiome

Author:

Rom Oren1ORCID,Liu Yuhao1,Liu Zhipeng2,Zhao Ying1ORCID,Wu Jianfeng3ORCID,Ghrayeb Alia4ORCID,Villacorta Luis5ORCID,Fan Yanbo6ORCID,Chang Lin1,Wang Lu7,Liu Cai7,Yang Dongshan8ORCID,Song Jun8ORCID,Rech Jason C.9ORCID,Guo Yanhong1,Wang Huilun1,Zhao Guizhen1,Liang Wenying1ORCID,Koike Yui1ORCID,Lu Haocheng1ORCID,Koike Tomonari1ORCID,Hayek Tony1011,Pennathur Subramaniam1ORCID,Xi Chuanwu3ORCID,Wen Bo7ORCID,Sun Duxin7ORCID,Garcia-Barrio Minerva T.1,Aviram Michael10,Gottlieb Eyal4ORCID,Mor Inbal4ORCID,Liu Wanqing12,Zhang Jifeng1ORCID,Chen Y. Eugene18ORCID

Affiliation:

1. Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA.

2. Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, IN 47907, USA.

3. Department of Environmental Health Sciences, University of Michigan School of Public Health, Ann Arbor, MI 48109, USA.

4. The Cancer Metabolism Laboratory, the Ruth and Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa 31096, Israel.

5. Department of Physiology, Morehouse School of Medicine, Atlanta, GA 30310, USA.

6. Department of Cancer Biology and Department of Internal Medicine, Division of Cardiovascular Health and Disease, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA.

7. Department of Pharmaceutical Sciences, College of Pharmacy, University of Michigan, Ann Arbor, MI 48109, USA.

8. Center for Advanced Models for Translational Sciences and Therapeutics, University of Michigan Medical Center, Ann Arbor, MI 48109, USA.

9. Michigan Center for Therapeutic Innovation, University of Michigan, Ann Arbor 48109, MI, USA.

10. The Lipid Research Laboratory, Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa 31096, Israel.

11. Department of Internal Medicine E, Rambam Health Care Campus, Haifa 31096, Israel.

12. Department of Pharmaceutical Sciences and Department of Pharmacology, Wayne State University, Detroit, MI 48201, USA.

Abstract

A glycine- and leucine-based tripeptide improves symptoms in a mouse model of nonalcoholic fatty liver disease, which lacks approved treatments.

Funder

National Heart, Lung, and Blood Institute

National Institute of Diabetes and Digestive and Kidney Diseases

American Heart Association

Michigan-Israel partnership for research and education

Michigan Center for Therapeutic Innovation

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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