Epigenetic markers associated with metformin response and intolerance in drug-naïve patients with type 2 diabetes-Reference-Cited by-同舟云学术

Epigenetic markers associated with metformin response and intolerance in drug-naïve patients with type 2 diabetes

Published:2020-09-16 Issue:561 Volume:12 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

García-Calzón Sonia¹²^ORCID,Perfilyev Alexander¹^ORCID,Martinell Mats³^ORCID,Ustinova Monta⁴,Kalamajski Sebastian⁵^ORCID,Franks Paul W.⁵^ORCID,Bacos Karl¹^ORCID,Elbere Ilze⁴,Pihlajamäki Jussi⁶⁷^ORCID,Volkov Petr¹,Vaag Allan⁸,Groop Leif⁹,Maziarz Marlena¹⁰^ORCID,Klovins Janis⁴¹¹^ORCID,Ahlqvist Emma⁹^ORCID,Ling Charlotte¹^ORCID

Affiliation:

1. Epigenetics and Diabetes Unit, Department of Clinical Sciences, Lund University Diabetes Centre, Scania University Hospital, 214 28 Malmö, Sweden.

2. Department of Nutrition, Food Science and Physiology, University of Navarra, 31008 Pamplona, Spain.

3. Department of Public Health and Caring Sciences, Uppsala University, 751 22 Uppsala, Sweden.

4. Latvian Biomedical Research and Study Centre, Rātsupītes Street 1, k-1, Riga LV-1067, Latvia.

5. Genetic and Molecular Epidemiology Unit, Department of Clinical Sciences, Lund University Diabetes Centre, 214 28 Malmö, Sweden.

6. Institute of Public Health and Clinical Nutrition, Internal Medicine, University of Eastern Finland, 70211 Kuopio, Finland.

7. Clinical Nutrition and Obesity Center, Kuopio University Hospital, 70210 Kuopio, Finland.

8. Type 2 Diabetes Biology Research, Steno Diabetes Center, 2820 Gentofte, Denmark.

9. Genomics, Diabetes and Endocrinology Unit, Department of Clinical Sciences, Lund University Diabetes Centre, Scania University Hospital, 214 28 Malmö, Sweden.

10. Bioinformatics Unit, Department of Clinical Sciences, Lund University Diabetes Centre, 214 28 Malmö, Sweden.

11. Faculty of Biology, University of Latvia, Riga LV-1004, Latvia.

Abstract

Blood-based epigenetic markers differentiate metformin responsiveness and tolerance in patients recently diagnosed with type 2 diabetes.

Funder

H2020 European Research Council

H2020 Marie Skłodowska-Curie Actions

European Research Council

European Foundation for the Study of Diabetes

Swedish Foundation for Strategic Research

Swedish Research Council Formas

Hjärt-Lungfonden