Reprogramming lipid metabolism prevents effector T cell senescence and enhances tumor immunotherapy-Reference-Cited by-同舟云学术

Reprogramming lipid metabolism prevents effector T cell senescence and enhances tumor immunotherapy

Published:2021-03-31 Issue:587 Volume:13 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Liu Xia¹^ORCID,Hartman Celine L.²,Li Lingyun¹,Albert Carolyn J.²,Si Fusheng¹^ORCID,Gao Aiqin¹,Huang Lan¹³,Zhao Yangjing¹³,Lin Wenli¹^ORCID,Hsueh Eddy C.⁴,Shen Lizong⁵^ORCID,Shao Qixiang³^ORCID,Hoft Daniel F.¹⁶^ORCID,Ford David A.²,Peng Guangyong¹⁶^ORCID

Affiliation:

1. Division of Infectious Diseases, Allergy and Immunology and Department of Internal Medicine, Saint Louis University School of Medicine, Saint Louis, MO 63104, USA.

2. Edward A. Doisy Department of Biochemistry and Molecular Biology and Center for Cardiovascular Research, Saint Louis University School of Medicine, Saint Louis, MO 63104, USA.

3. Department of Immunology, Key Laboratory of Medical Science and Laboratory Medicine of Jiangsu Province, School of Medicine, Jiangsu University, Zhenjiang 212013, P. R. China.

4. Division of General Surgery and Department of Surgery, Saint Louis University School of Medicine, Saint Louis, MO 63104, USA.

5. Division of Gastrointestinal Surgery, Department of General Surgery, First Affiliated Hospital, Nanjing Medical University, Nanjing 210029, P. R. China.

6. Department of Molecular Microbiology and Immunology, Saint Louis University School of Medicine, MO 63104, USA.

Abstract

Reprogramming lipid metabolism reverses effector T cell senescence and enhances antitumor immunity in mouse models.

Funder

National Institutes of Health

Melanoma Research Alliance

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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1. Immune Checkpoint Blockade: A Common Denominator Approach to Cancer Therapy