Neoantigen responses, immune correlates, and favorable outcomes after ipilimumab treatment of patients with prostate cancer-Reference-Cited by-同舟云学术

Neoantigen responses, immune correlates, and favorable outcomes after ipilimumab treatment of patients with prostate cancer

Published:2020-04 Issue:537 Volume:12 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Subudhi Sumit K.¹^ORCID,Vence Luis²^ORCID,Zhao Hao²^ORCID,Blando Jorge²,Yadav Shalini S.²,Xiong Qing²,Reuben Alexandre³^ORCID,Aparicio Ana¹^ORCID,Corn Paul G.¹^ORCID,Chapin Brian F.⁴,Pisters Louis L.⁴,Troncoso Patricia⁵,Tidwell Rebecca Slack⁶^ORCID,Thall Peter⁶,Wu Chang-Jiun⁷^ORCID,Zhang Jianhua⁷^ORCID,Logothetis Christopher L.¹^ORCID,Futreal Andrew⁷^ORCID,Allison James P.²⁸^ORCID,Sharma Padmanee¹²⁸^ORCID

Affiliation:

1. Department of Genitourinary Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.

2. Immunotherapy Platform, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.

3. Department of Thoracic Head and Neck Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.

4. Department of Urology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.

5. Department of Pathology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.

6. Department of Biostatistics, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.

7. Department of Genomic Medicine, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.

8. Department of Immunology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.

Abstract

Low–tumor mutational burden prostate tumors express neoantigens that elicit T cell responses associated with favorable clinical outcomes to ipilimumab.

Funder

Prostate Cancer Foundation

University of Texas MD Anderson Cancer Center

Stand Up To Cancer

Parker Institute for Cancer Immunotherapy

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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