Functional effects of chimeric antigen receptor co-receptor signaling domains in human regulatory T cells-Reference-Cited by-同舟云学术

Functional effects of chimeric antigen receptor co-receptor signaling domains in human regulatory T cells

Published:2020-08-19 Issue:557 Volume:12 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Dawson Nicholas A. J.¹²^ORCID,Rosado-Sánchez Isaac²³^ORCID,Novakovsky German E.²⁴^ORCID,Fung Vivian C. W.²⁵^ORCID,Huang Qing²⁵,McIver Emma²⁵,Sun Grace²⁵,Gillies Jana²⁵,Speck Madeleine²⁵,Orban Paul C.²⁵^ORCID,Mojibian Majid²⁵,Levings Megan K.²³⁵^ORCID

Affiliation:

1. Department of Medicine, University of British Columbia, Vancouver, BC V5Z 4H4, Canada.

2. BC Children’s Hospital Research Institute, Vancouver, BC V5Z 4H4, Canada.

3. School of Biomedical Engineering, University of British Columbia, Vancouver, BC V5Z 4H4, Canada.

4. Department of Medical Genetics, University of British Columbia, Vancouver, BC V5Z 4H4, Canada.

5. Department of Surgery, University of British Columbia, Vancouver, BC V5Z 4H4, Canada.

Abstract

Comparison of 10 co-receptor variant CARs revealed a requirement for CD28wt for optimal suppression by human regulatory T cells.

Funder

Canadian Institutes of Health Research

TxCell S.A.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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